DIURETICS USE IN HYPERTENSION & OTHER INDICATIONS

DIURETICS USE IN HYPERTENSION & OTHER INDICATIONS   Thiazide Diuretics Became available in late 1950s. Diuretic therapy for hypertension originated in 1937. The term thiazide diuretic, includes all diuretics believed to act on distal tubule. Chlorothiazide, a benzothiadiazine derivative. Discovered: while searching for carbonic anhydrase inhibitor. Primary action: upstream portion of distal convoluted tubules. Interfere […]